Serveur d'exploration sur la COVID chez les séniors

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The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea.

Identifieur interne : 000175 ( Main/Exploration ); précédent : 000174; suivant : 000176

The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea.

Auteurs : Mi Kyung Kim [Corée du Sud] ; Jae Han Jeon [Corée du Sud] ; Sung Woo Kim [Corée du Sud] ; Jun Sung Moon [Corée du Sud] ; Nan Hee Cho [Corée du Sud] ; Eugene Han [Corée du Sud] ; Ji Hong You [Corée du Sud] ; Ji Yeon Lee [Corée du Sud] ; Miri Hyun [Corée du Sud] ; Jae Seok Park [Corée du Sud] ; Yong Shik Kwon [Corée du Sud] ; Yeon Kyung Choi [Corée du Sud] ; Ki Tae Kwon [Corée du Sud] ; Shin Yup Lee [Corée du Sud] ; Eon Ju Jeon [Corée du Sud] ; Jin Woo Kim [Corée du Sud] ; Hyo Lim Hong [Corée du Sud] ; Hyun Hee Kwon [Corée du Sud] ; Chi Young Jung [Corée du Sud] ; Yin Young Lee [Corée du Sud] ; Eunyeoung Ha [Corée du Sud] ; Seung Min Chung [Corée du Sud] ; Jian Hur [Corée du Sud] ; June Hong Ahn [Corée du Sud] ; Na Young Kim [Corée du Sud] ; Shin Woo Kim [Corée du Sud] ; Hyun Ha Chang [Corée du Sud] ; Yong Hoon Lee [Corée du Sud] ; Jaehee Lee [Corée du Sud] ; Keun Gyu Park [Corée du Sud] ; Hyun Ah Kim [Corée du Sud] ; Ji Hyun Lee [Corée du Sud]

Source :

RBID : pubmed:32794386

Descripteurs français

English descriptors

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes.

METHODS

We conducted a multi-center observational study of 1,082 adult inpatients (aged ≥18 years) who were admitted to one of five university hospitals in Daegu because of the severity of their COVID-19-related disease. The demographic, laboratory, and radiologic findings, and the mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM. In addition, 1:1 propensity score (PS)-matching was conducted with the DM group.

RESULTS

Compared with the non-DM group (

CONCLUSION

DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care.


DOI: 10.4093/dmj.2020.0146
PubMed: 32794386
PubMed Central: PMC7453989


Affiliations:


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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
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<name sortKey="Hur, Jian" sort="Hur, Jian" uniqKey="Hur J" first="Jian" last="Hur">Jian Hur</name>
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<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
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<name sortKey="Ahn, June Hong" sort="Ahn, June Hong" uniqKey="Ahn J" first="June Hong" last="Ahn">June Hong Ahn</name>
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<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
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<name sortKey="Kim, Na Young" sort="Kim, Na Young" uniqKey="Kim N" first="Na Young" last="Kim">Na Young Kim</name>
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<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
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<name sortKey="Kim, Shin Woo" sort="Kim, Shin Woo" uniqKey="Kim S" first="Shin Woo" last="Kim">Shin Woo Kim</name>
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<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
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<name sortKey="Lee, Yong Hoon" sort="Lee, Yong Hoon" uniqKey="Lee Y" first="Yong Hoon" last="Lee">Yong Hoon Lee</name>
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<name sortKey="Lee, Jaehee" sort="Lee, Jaehee" uniqKey="Lee J" first="Jaehee" last="Lee">Jaehee Lee</name>
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<name sortKey="Park, Keun Gyu" sort="Park, Keun Gyu" uniqKey="Park K" first="Keun Gyu" last="Park">Keun Gyu Park</name>
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<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea. hyunah1118@dsmc.or.kr.</nlm:affiliation>
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<name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name>
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<title xml:lang="en">The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea.</title>
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<name sortKey="Kim, Mi Kyung" sort="Kim, Mi Kyung" uniqKey="Kim M" first="Mi Kyung" last="Kim">Mi Kyung Kim</name>
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<name sortKey="Jeon, Jae Han" sort="Jeon, Jae Han" uniqKey="Jeon J" first="Jae Han" last="Jeon">Jae Han Jeon</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Moon, Jun Sung" sort="Moon, Jun Sung" uniqKey="Moon J" first="Jun Sung" last="Moon">Jun Sung Moon</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cho, Nan Hee" sort="Cho, Nan Hee" uniqKey="Cho N" first="Nan Hee" last="Cho">Nan Hee Cho</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Han, Eugene" sort="Han, Eugene" uniqKey="Han E" first="Eugene" last="Han">Eugene Han</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="You, Ji Hong" sort="You, Ji Hong" uniqKey="You J" first="Ji Hong" last="You">Ji Hong You</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Ji Yeon" sort="Lee, Ji Yeon" uniqKey="Lee J" first="Ji Yeon" last="Lee">Ji Yeon Lee</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hyun, Miri" sort="Hyun, Miri" uniqKey="Hyun M" first="Miri" last="Hyun">Miri Hyun</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Park, Jae Seok" sort="Park, Jae Seok" uniqKey="Park J" first="Jae Seok" last="Park">Jae Seok Park</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kwon, Yong Shik" sort="Kwon, Yong Shik" uniqKey="Kwon Y" first="Yong Shik" last="Kwon">Yong Shik Kwon</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Choi, Yeon Kyung" sort="Choi, Yeon Kyung" uniqKey="Choi Y" first="Yeon Kyung" last="Choi">Yeon Kyung Choi</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kwon, Ki Tae" sort="Kwon, Ki Tae" uniqKey="Kwon K" first="Ki Tae" last="Kwon">Ki Tae Kwon</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Shin Yup" sort="Lee, Shin Yup" uniqKey="Lee S" first="Shin Yup" last="Lee">Shin Yup Lee</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jeon, Eon Ju" sort="Jeon, Eon Ju" uniqKey="Jeon E" first="Eon Ju" last="Jeon">Eon Ju Jeon</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kim, Jin Woo" sort="Kim, Jin Woo" uniqKey="Kim J" first="Jin Woo" last="Kim">Jin Woo Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hong, Hyo Lim" sort="Hong, Hyo Lim" uniqKey="Hong H" first="Hyo Lim" last="Hong">Hyo Lim Hong</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kwon, Hyun Hee" sort="Kwon, Hyun Hee" uniqKey="Kwon H" first="Hyun Hee" last="Kwon">Hyun Hee Kwon</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jung, Chi Young" sort="Jung, Chi Young" uniqKey="Jung C" first="Chi Young" last="Jung">Chi Young Jung</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Yin Young" sort="Lee, Yin Young" uniqKey="Lee Y" first="Yin Young" last="Lee">Yin Young Lee</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ha, Eunyeoung" sort="Ha, Eunyeoung" uniqKey="Ha E" first="Eunyeoung" last="Ha">Eunyeoung Ha</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chung, Seung Min" sort="Chung, Seung Min" uniqKey="Chung S" first="Seung Min" last="Chung">Seung Min Chung</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hur, Jian" sort="Hur, Jian" uniqKey="Hur J" first="Jian" last="Hur">Jian Hur</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ahn, June Hong" sort="Ahn, June Hong" uniqKey="Ahn J" first="June Hong" last="Ahn">June Hong Ahn</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kim, Na Young" sort="Kim, Na Young" uniqKey="Kim N" first="Na Young" last="Kim">Na Young Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kim, Shin Woo" sort="Kim, Shin Woo" uniqKey="Kim S" first="Shin Woo" last="Kim">Shin Woo Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chang, Hyun Ha" sort="Chang, Hyun Ha" uniqKey="Chang H" first="Hyun Ha" last="Chang">Hyun Ha Chang</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Yong Hoon" sort="Lee, Yong Hoon" uniqKey="Lee Y" first="Yong Hoon" last="Lee">Yong Hoon Lee</name>
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<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Jaehee" sort="Lee, Jaehee" uniqKey="Lee J" first="Jaehee" last="Lee">Jaehee Lee</name>
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<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Park, Keun Gyu" sort="Park, Keun Gyu" uniqKey="Park K" first="Keun Gyu" last="Park">Keun Gyu Park</name>
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<nlm:affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kim, Hyun Ah" sort="Kim, Hyun Ah" uniqKey="Kim H" first="Hyun Ah" last="Kim">Hyun Ah Kim</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea. hyunah1118@dsmc.or.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Ji Hyun" sort="Lee, Ji Hyun" uniqKey="Lee J" first="Ji Hyun" last="Lee">Ji Hyun Lee</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea. jhlee9@cu.ac.kr.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu</wicri:regionArea>
<wicri:noRegion>Daegu</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Diabetes & metabolism journal</title>
<idno type="eISSN">2233-6087</idno>
<imprint>
<date when="2020" type="published">2020</date>
</imprint>
</series>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Alanine Transaminase (metabolism)</term>
<term>Angiotensin-Converting Enzyme Inhibitors (therapeutic use)</term>
<term>Aspartate Aminotransferases (metabolism)</term>
<term>Betacoronavirus (MeSH)</term>
<term>C-Reactive Protein (metabolism)</term>
<term>Case-Control Studies (MeSH)</term>
<term>Comorbidity (MeSH)</term>
<term>Coronavirus Infections (metabolism)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (physiopathology)</term>
<term>Diabetes Mellitus (drug therapy)</term>
<term>Diabetes Mellitus (epidemiology)</term>
<term>Diabetes Mellitus (metabolism)</term>
<term>Dipeptidyl-Peptidase IV Inhibitors (therapeutic use)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Length of Stay (statistics & numerical data)</term>
<term>Logistic Models (MeSH)</term>
<term>Lymphocytosis (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Multivariate Analysis (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (metabolism)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Prognosis (MeSH)</term>
<term>Propensity Score (MeSH)</term>
<term>Proportional Hazards Models (MeSH)</term>
<term>Quarantine (statistics & numerical data)</term>
<term>Republic of Korea (epidemiology)</term>
<term>Risk Factors (MeSH)</term>
<term>Severity of Illness Index (MeSH)</term>
<term>Thrombocytopenia (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Alanine transaminase (métabolisme)</term>
<term>Analyse multifactorielle (MeSH)</term>
<term>Aspartate aminotransferases (métabolisme)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Comorbidité (MeSH)</term>
<term>Diabète (métabolisme)</term>
<term>Diabète (traitement médicamenteux)</term>
<term>Diabète (épidémiologie)</term>
<term>Durée du séjour (statistiques et données numériques)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hyperlymphocytose (MeSH)</term>
<term>Indice de gravité de la maladie (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (métabolisme)</term>
<term>Infections à coronavirus (physiopathologie)</term>
<term>Inhibiteurs de l'enzyme de conversion de l'angiotensine (usage thérapeutique)</term>
<term>Inhibiteurs de la dipeptidyl-peptidase IV (usage thérapeutique)</term>
<term>Modèles des risques proportionnels (MeSH)</term>
<term>Modèles logistiques (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (métabolisme)</term>
<term>Pneumopathie virale (physiopathologie)</term>
<term>Pronostic (MeSH)</term>
<term>Protéine C-réactive (métabolisme)</term>
<term>Quarantaine (statistiques et données numériques)</term>
<term>République de Corée (épidémiologie)</term>
<term>Score de propension (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Thrombopénie (MeSH)</term>
<term>Études cas-témoins (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Alanine Transaminase</term>
<term>Aspartate Aminotransferases</term>
<term>C-Reactive Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Angiotensin-Converting Enzyme Inhibitors</term>
<term>Dipeptidyl-Peptidase IV Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en">
<term>Republic of Korea</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Diabetes Mellitus</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Diabetes Mellitus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Diabetes Mellitus</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Alanine transaminase</term>
<term>Aspartate aminotransferases</term>
<term>Diabète</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Protéine C-réactive</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr">
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en">
<term>Length of Stay</term>
<term>Quarantine</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr">
<term>Durée du séjour</term>
<term>Quarantaine</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr">
<term>Diabète</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Inhibiteurs de l'enzyme de conversion de l'angiotensine</term>
<term>Inhibiteurs de la dipeptidyl-peptidase IV</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Diabète</term>
<term>République de Corée</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Betacoronavirus</term>
<term>Case-Control Studies</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Lymphocytosis</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Pandemics</term>
<term>Prognosis</term>
<term>Propensity Score</term>
<term>Proportional Hazards Models</term>
<term>Risk Factors</term>
<term>Severity of Illness Index</term>
<term>Thrombocytopenia</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse multifactorielle</term>
<term>Betacoronavirus</term>
<term>Comorbidité</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hyperlymphocytose</term>
<term>Indice de gravité de la maladie</term>
<term>Modèles des risques proportionnels</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Pronostic</term>
<term>Score de propension</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Thrombopénie</term>
<term>Études cas-témoins</term>
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<front>
<div type="abstract" xml:lang="en">
<p>
<b>BACKGROUND</b>
</p>
<p>Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>We conducted a multi-center observational study of 1,082 adult inpatients (aged ≥18 years) who were admitted to one of five university hospitals in Daegu because of the severity of their COVID-19-related disease. The demographic, laboratory, and radiologic findings, and the mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM. In addition, 1:1 propensity score (PS)-matching was conducted with the DM group.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>Compared with the non-DM group (</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care.</p>
</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">32794386</PMID>
<DateCompleted>
<Year>2020</Year>
<Month>09</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>09</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">2233-6087</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>44</Volume>
<Issue>4</Issue>
<PubDate>
<Year>2020</Year>
<Month>08</Month>
</PubDate>
</JournalIssue>
<Title>Diabetes & metabolism journal</Title>
<ISOAbbreviation>Diabetes Metab J</ISOAbbreviation>
</Journal>
<ArticleTitle>The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea.</ArticleTitle>
<Pagination>
<MedlinePgn>602-613</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4093/dmj.2020.0146</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND">Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes.</AbstractText>
<AbstractText Label="METHODS">We conducted a multi-center observational study of 1,082 adult inpatients (aged ≥18 years) who were admitted to one of five university hospitals in Daegu because of the severity of their COVID-19-related disease. The demographic, laboratory, and radiologic findings, and the mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM. In addition, 1:1 propensity score (PS)-matching was conducted with the DM group.</AbstractText>
<AbstractText Label="RESULTS">Compared with the non-DM group (
<i>n</i>
=847), patients with DM (
<i>n</i>
=235) were older, exhibited higher mortality, and required more intensive care. Even after PS-matching, patients with DM exhibited more severe disease, and DM remained a prognostic factor for higher mortality (hazard ratio, 2.40; 95% confidence interval, 1.38 to 4.15). Subgroup analysis revealed that the presence of DM was associated with higher mortality, especially in older people (≥70 years old). Prior use of a dipeptidyl peptidase-4 inhibitor or a renin-angiotensin system inhibitor did not affect mortality or the clinical severity of the disease.</AbstractText>
<AbstractText Label="CONCLUSION">DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care.</AbstractText>
<CopyrightInformation>Copyright © 2020 Korean Diabetes Association.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y" EqualContrib="Y">
<LastName>Kim</LastName>
<ForeName>Mi Kyung</ForeName>
<Initials>MK</Initials>
<Identifier Source="ORCID">0000-0001-5750-3598</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y">
<LastName>Jeon</LastName>
<ForeName>Jae Han</ForeName>
<Initials>JH</Initials>
<Identifier Source="ORCID">0000-0002-9217-968X</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Sung Woo</ForeName>
<Initials>SW</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Moon</LastName>
<ForeName>Jun Sung</ForeName>
<Initials>JS</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Cho</LastName>
<ForeName>Nan Hee</ForeName>
<Initials>NH</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Han</LastName>
<ForeName>Eugene</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
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<ForeName>Ji Hong</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Ji Yeon</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Hyun</LastName>
<ForeName>Miri</ForeName>
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<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Park</LastName>
<ForeName>Jae Seok</ForeName>
<Initials>JS</Initials>
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<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Kwon</LastName>
<ForeName>Yong Shik</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Choi</LastName>
<ForeName>Yeon Kyung</ForeName>
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<Affiliation>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kwon</LastName>
<ForeName>Ki Tae</ForeName>
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<Affiliation>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Shin Yup</ForeName>
<Initials>SY</Initials>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Jeon</LastName>
<ForeName>Eon Ju</ForeName>
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<Affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Jin Woo</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Hong</LastName>
<ForeName>Hyo Lim</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kwon</LastName>
<ForeName>Hyun Hee</ForeName>
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</AffiliationInfo>
</Author>
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<ForeName>Chi Young</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Yin Young</ForeName>
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<ForeName>Eunyeoung</ForeName>
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<LastName>Chung</LastName>
<ForeName>Seung Min</ForeName>
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<Affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Hur</LastName>
<ForeName>Jian</ForeName>
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<Affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ahn</LastName>
<ForeName>June Hong</ForeName>
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<Affiliation>Department of Internal Medicine, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Na Young</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Shin Woo</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Chang</LastName>
<ForeName>Hyun Ha</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Yong Hoon</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Jaehee</ForeName>
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<Affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Park</LastName>
<ForeName>Keun Gyu</ForeName>
<Initials>KG</Initials>
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<Affiliation>Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Hyun Ah</ForeName>
<Initials>HA</Initials>
<Identifier Source="ORCID">0000-0002-9125-7156</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea. hyunah1118@dsmc.or.kr.</Affiliation>
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<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Ji Hyun</ForeName>
<Initials>JH</Initials>
<Identifier Source="ORCID">0000-0002-5671-0875</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, Korea. jhlee9@cu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y">
<Grant>
<Agency>Daegu Medical Association COVID-19 Scientific Committee</Agency>
<Country>International</Country>
</Grant>
</GrantList>
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<PublicationType UI="D064888">Observational Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2020</Year>
<Month>08</Month>
<Day>12</Day>
</ArticleDate>
</Article>
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<Country>Korea (South)</Country>
<MedlineTA>Diabetes Metab J</MedlineTA>
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<ISSNLinking>2233-6079</ISSNLinking>
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<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054873">Dipeptidyl-Peptidase IV Inhibitors</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>9007-41-4</RegistryNumber>
<NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance>
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<MeshHeading>
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</MeshHeading>
<MeshHeading>
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<MeshHeading>
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<MeshHeading>
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<MeshHeading>
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<MeshHeading>
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<MeshHeading>
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<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
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<MeshHeading>
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<MeshHeading>
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<MeshHeading>
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<MeshHeading>
<DescriptorName UI="D056910" MajorTopicYN="N" Type="Geographic">Republic of Korea</DescriptorName>
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<Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">Diabetes mellitus</Keyword>
<Keyword MajorTopicYN="Y">Mortality</Keyword>
<Keyword MajorTopicYN="Y">Prognosis</Keyword>
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<CoiStatement>No potential conflict of interest relevant to this article was reported.</CoiStatement>
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<Month>06</Month>
<Day>26</Day>
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<Month>07</Month>
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